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| University of Pennsylvania Museum of Archaeology and Anthroplogy Museum provides a source of understanding about the history, nature and significance of the world's cultural heritage.
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Historical Society of Berks County Society operates a museum and research library.
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Fort Hunter Mansion Mansion and surrounding park invite visitors to explore Pennsylvania history.
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Virtual Museum of Coal Mining in Western Pennsylvania Index to the coal mines and companies that mined the Bituminous coal seams of Westmoreland County, Pennsylvania.
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Carnegie Museum of Natural History Museum shares knowledge of evolution and environmental change and their interactions with life on Earth.
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Glencairn Museum Museum educates visitors about the history of religion.
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Rosenbach Museum & Library Museum houses collections of rare books and manuscripts, art and antiquities.
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Houdini Museum Museum dedicated to Harry Houdini and his magic.
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La Salle University Art Museum Museum functions as a cultural resource for the university and the surrounding communities.
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Reading Public Museum Museum and planetarium serving south-central and southeastern Pennsylvania.
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George Westinghouse Museum Museum is a tribute to George Westinghouse and the men and women of the Westinghouse companies.
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Hershey Museum Museum of Native American and Pennsylvania German objects as well as objects relating to Milton Hershey.
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Meadowcroft Museum of Rural Life Outdoor museum preserves the history of life on the land in western Pennsylvania.
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National Watch & Clock Museum Museum features a horological collection.
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Museum of Bus Transportation Museum tells the story of bus transport in the US.
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Eastern State Penitentiary Historic Site Historic site of a prison started in 1776.
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Pennsylvania Academy of the Fine Arts Art museum and school featuring collections of 18th, 19th and 20th-century American paintings, sculptures and works on paper.
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Balch Institute for Ethnic Studies Museum, library and archive dedicated to collecting and interpreting America's multicultural heritage.
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Andy Warhol Museum Museum features permanent collections of art and archives, special exhibitions including the work of other artists, programs and special events.
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Heritage Map Museum Museum specializes in the sale of 15th- to 19th-century maps and atlases.
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Paley Design Center Center is located on the campus of Philadelphia College of Textiles & Science.
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Valley Forge Historical Society Museum Museum houses artifacts related to the revolutionary army's encampment at Valley Forge in the winter of 1777-78.
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Johnstown Area Heritage Association Organization operates the Johnstown Area Discovery Center, the Wagner-Ritter House and Museum and the Flood Museum.
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National Canal Museum Explores America's canal heritage. Located in Easton, Pennsylvania.
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Galleries at Moore, The Galleries include the Levy Gallery and the Goldie Paley Gallery. Located on the campus of Moore College of Art and Design.
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Carnegie Science Center Center dedicated to educating, entertaining, exciting and inspiring through programs in science and technology.
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Franklin Institute Science Museum Museum houses science exhibits, an IMAX theater and planetarium.
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Heritage Center Museum of Lancaster County Museum collects, preserves and interprets Lancaster County's history and decorative arts.
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Palmer Museum of Art Art museum at Pennsylvania State University.
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Juniata College Museum of Art Museum provides a cultural center for Juniata College and the central Pennsylvania community.
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Philadelphia Museum of Art Museum of visual art.
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Brandywine River Museum Museum exhibits American art in a 19th-century gristmill.
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Pittsburgh Children's Museum Museum provides hands-on exhibits and programs.
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North Museum of Natural History and Science Museum about science and the natural world.
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Pocono Indian Museum Museum shows the history of the Delaware Indian.
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Mutter Museum Medical museum maintained by the College of Physicians of Philadelphia.
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